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![]() It cannot be changed without changing our thinking. The world as we have created it is a process of our thinking. I don’t think of all the misery but of the beauty that still remains. Barbara KingsolverĮverything has beauty, but not everyone sees it. And that someone else’s pain is as meaningful as your own. It’s the capacity to understand that every war is both won and lost. Mahatma GandhiĮmpathy is really the opposite of spiritual meanness. Martin YanĪn eye for an eye only ends up making the whole world blind. Happiness comes when you believe that you have done something truly meaningful. It has nothing to do with how much applause you get or how many people praise you. Everyone who is in your life are meant to be in your journey but not all of them are meant to stay till the end. Time is too slow for those who wait, too swift for those who fear, too long for those who grieve, too short for those who rejoice, but for those who love, time is the eternity. Life is not about waiting for the storm to pass but learning to dance in the rain. The great man is he who does not lose his child’s heart. Marilyn Monroeįor beautiful eyes, look for the good in others for beautiful lips, speak only words of kindness and for poise, walk with the knowledge that you are never alone. People change so that you can learn to let go, things go wrong so that you can appreciate them when they’re right, you believe lies so you eventually learn to trust no one but yourself, and sometimes good things fall apart so better things can fall together. I believe that everything happens for a reason. Overcoming them is what makes life meaningful. Sophia LorenĬhallenges are what make life interesting. Mistakes are part of the dues that one pays for a full life. In the middle of difficulty lies opportunity. Sometimes courage is the quiet voice at the end of the day saying, I will try again tomorrow. Tryon EdwardsĬourage doesn’t always roar. Prejudices are rarely overcome by argument not being founded in reason they cannot be destroyed by logic. The greatest glory in living lies not in never falling, but in rising every time we fall. Tom Bodettĭo not take life too seriously. They say a person needs just three things to be truly happy in this world: Someone to love, something to do, and something to hope for. Oscar Wildeīe who you are and say what you feel because those who mind don’t matter and those who matter don’t mind. Maya Angelouīe yourself everyone else is already taken. Life is not measured by the number of breaths we take, but by the moments that take our breath away. You will face many defeats in life, but never let yourself be defeated. Stephen Kingĭon’t cry because it’s over, smile because it happened. Stephen Furtickĭon’t judge each day by the harvest you reap but by the seeds that you plant. The reason why we struggle with insecurity is because we compare our behind the scenes with everyone else’s highlight reel. Success is not final, failure is not fatal: it is the courage to continue that counts. Life is what happens when you’re busy making other plans. You were never created to live depressed, defeated, guilty, condemned, ashamed or unworthy. Jim KwikĮither you run the day or the day runs you. Great things always begin from the inside. If broken by an inside force, life begins. If an egg is broken by an outside force, life ends. But I have promises to keep, and miles to go before I sleep. If you concentrate on what you don’t have, you will never, ever have enough. Harriet Tubmanīe thankful for what you have you’ll end up having more. ![]() I could have freed 1000 more if only they knew they were slaves. You are only as free as you think you are and freedom will always be as real as you believe it to be. Here are the best deep and meaningful quotes that make you think and see life different: Best Meaningful Quotes Also, visit to think wonderful thoughts with our Peter Pan Quotes with images because there are so many little gems of quotes from Peter Pan. In the busy lives, we need some cute meaningful quotes and sayings about life and love to think about. We hope these deep and meaningful quotes that make you think will help you to regain that perspective. ![]() Sometimes in life, it’s good to just stop what you’re doing, take a deep breath and get some perspective. ![]() ![]() ![]() The founder of Ladies Get Paid, Claire Wasserman is an educator, coach, and podcaster who helps women navigate their professional options to find fulfilling career paths. And remember, by speaking up for yourself, you’re speaking up for all of us. Bonus points if they do PR or marketing, since they can probably help you spin your argument to demonstrate its value for the company and not just you.Īs long as you’re well-researched and respectful, you have nothing to fear. Asking for continued education (like going to Ladies Get Paid workshops!) will teach you the skills you can use to contribute to your team.įind someone with whom you can practice of all of these scenarios so you’re prepared with a response for any pushback that you’ll likely encounter. Though it benefits you, everything you ask for should be positioned in terms of how it serves the company. Before you discuss it with them, already prioritize in your mind which non-monetary things are most valuable to you. You can also negotiate other aspects of your benefits package, like paid time off or a flexible schedule: This is what’s referred to as “full compensation.” You want to bring this up after you’ve negotiated for money. Make sure you know exactly what they need to see from you to get a raise. If they still won’t budge, ask them when you can next discuss this with them. ![]() Reiterate the market rate and re-state that you’re a top performer. Be aware of your body language don’t cross your arms, lean forward, et cetera. Houzz is your one stop shop for all things home. ![]() Instead of saying “the situation isn’t working,” bring a positive attitude and problem-solving approach to a negotiation. “I understand that the budget is tight this year, so what can we do to find a solution that works for both of us?” Acknowledging their concerns and goals will go a long way. Houzz is a trusted and reputable home design and remodeling website that aims to connect homeowners with the ideas, professionals and tools they need to complete any home renovation project. Make sure you’re not making statements or asking questions that can elicit a "no" answer. “Did I understand correctly that you are saying.”Īnticipate the pressures your manager is under and proactively address them. “I’m eager to hear your thoughts on this.” Continually confirm that you’re on the same page with phrases like these: Make sure you’re conducting a dialogue rather than presenting, making a demand, and waiting for a decision. “I’d like to talk about my performance and my career path here.”Īctively solicit feedback as you go along. “I’d like to schedule a time for us to chat about how I’m performing and how I can move ahead at this company.” ![]() ![]() ![]() That same day, Thoughtworks reported that its revenue had increased 8.3% between the fourth quarter of 2022 and the fourth quarter of 2021. TechCrunch noted that the company "did not dispute" the figure when reached for comment on March 1.Īccording to TechCrunch, Thoughtworks "initially informed" the affected employees about the decision on February 28. Thoughtworks, a software consultancy firm, reportedly laid off 500 employees or 4% of its global workforce, according to TechCrunch. Screenshot of Guo Xiao from the Thoughtworks website. ![]() That day, CEO Guo Xiao said in the company's earnings release that it was "pleased" with its performance in the fourth quarter of 2022. Thoughtworks laid off 500 employees on February 28. At the time, Zuckerberg called the layoffs a "last resort." The job cuts come less than 5 months after Meta slashed 11,000 workers, or about 13% of its workforce, in November. "In a small number of cases, it may take through the end of the year to complete these changes," he wrote. In the post, Zuckerberg said that members of Meta's recruiting team would learn about the fate of their jobs in March, while tech workers would find out in late April, and business groups would find out in May. "My hope is to make these org changes as soon as possible in the year so we can get past this period of uncertainty and focus on the critical work ahead," Zuckerberg wrote in a post on Facebook announcing the layoffs. Zuckerberg also said the company would close around 5,000 open roles that haven't yet been filled as part of the company's effort to downsize. Roughly 10,000 Meta workers will find out that their jobs have been cut between March and May, according to an announcement by the company's founder and CEO, Mark Zuckerberg. Opendoor last made cuts in November 2022, laying off 550 workers or about 18% of its staff. Impacted team members will receive severance pay, extended health benefits, and job transition support. The spokesperson noted that the cuts have been made to "better align our operational costs with the anticipated near-term market opportunity, while maintaining our critical technology investments that will continue to drive the business long term." On Tuesday, home flipping giant Opendoor said it was cutting 560 jobs, or 22% of its workforce, citing a souring housing market.Ī spokesperson for Opendoor told Insider by email,"We've been weathering a sharp transition in the housing market – the steepest and fastest rate increase by the Fed in 40 years, the more than doubling of mortgage rates from historic lows, and the hit to home affordability have driven an approximately 30% decline in new listings from peak levels last year." Opendoor announced it was cutting 560 jobs on Tuesday. Account icon An icon in the shape of a person's head and shoulders. ![]() ![]() As a result, Penguin Random House lost a huge chunk of market share, from 25 per cent to 21 per cent, according to a chart displayed by PRH lawyers. Dohle pointed out that while Penguin Random House was failing to grow after the merger, the rest of the book trade expanded handsomely-from $9 billion to $11 billion between 20. He showed that its failure was far more monumental than it appeared, at least to me. Along the way, he had some interesting things to say about the Penguin debacle. ![]() The new firm, said Markus Dohle, the same man who failed to find synergies between Penguin and Random House, would “create the future of books.”ĭohle was called to the witness stand last week to answer questions about his Simon & Schuster bid. Yet in 2020, Penguin Random House decided to repeat the whole process, striking a deal to buy Simon & Schuster, once again at a ridiculously high valuation, once again promising that magic would result from the increased scale, improved access to talent, innovation, etc. Most of the $3.5 billion purchase price was wasted. ![]() The point is that seven years down the road, Penguin Random House remained exactly the sum of its parts, minus 2000 workers. And the Obamas each knocked one out of the park. Also, e-books and audiobooks improved the profitability of all publishers. As far as I can tell, the improved profitability was achieved the old-fashioned way: the payroll shrunk from a high of 12,800 to 10,800. But they didn’t grow as a result of the combined firm’s increased scale, new competitive muscle, better talent, new markets, new products, or innovations. Profits are up, which might be considered a good sign. Revenues were about $4 billion, and that’s where they’ve been ever since (leaving aside a nice bump in 2019, the year of Michelle Obama). The first full year of a combined Penguin Random House was 2014. Over the next several years, Bertelsmann doubled down on its bet, scooping up the remaining 47 per cent of Penguin in two separate transactions to eventually own it outright. Penguin Random House would have to be far more than the sum of its parts to justify that price. Bertelsmann’s purchase price valued Penguin at $3.5 billion, or more than twenty times its annual profits of $171 million. Markus Dohle, CEO of Penguin Random House, is lucky to get a mid-level account manager on the phone at Amazon.īut the deal went ahead and expectations for the new Penguin Random House were sky high. Random House had its pick of talent, all the size it needed to negotiate with Barnes & Noble, and it would never be in the same league as Amazon. Together they would have the scale to stand up to bookselling chains like Barnes & Noble and the massive digital players, Amazon and Apple. It was said at the time that the two publishers, with combined revenues of $3.9 billion, would be able to share costs, attract better talent, take more risks, offer new products, develop new markets, and otherwise innovate. In 2012, it struck the richest deal in book publishing history, acquiring 53 per cent of Penguin Books, which it then merged with Random House to make the biggest publisher even bigger. It needs to be fixed or jettisoned.īertelsmann decided to fix Random House. When an asset at a public company does not contribute to growth it is dead weight. That is the whole game for public companies. People buy shares in publicly listed companies because they believe the entity will grow and produce larger profits in the future, making the share price rise and the investor happy. ![]() Growth matters, especially to Random House’s parent company, Bertelsmann SE, a public company. It was the biggest publishing company on the planet but it had ceased to grow. At the end of the aughts, it had revenues of 2.3 billion and a profit margin of 9 per cent. Week two has been relatively slow so I’m going to step back and look at the biggest story to emerge from the trial thus far: the revelation that Penguin Random House is a vampire corporation.Īt the beginning of the millennium, Random House (pre-Penguin) had revenues of $2.3 billion (all US figures) and a profit margin of 9 per cent. Our coverage of the trial’s first week is here. The Department of Justice (DOJ) is suing to block Penguin Random House’s acquisition of Simon & Schuster. ![]() ![]() ![]() There are three main types of observational studies: cohort studies, case–control studies, and cross-sectional studies. Utilizes primary sources from libraries, archives, or other repositories to investigate a research questionĪnalyzing US Census data or telephone records Observing a child or group of children over the course of their time in elementary school Investigates a person or group of people over time, with the idea that close investigation can later be generalized to other people or groups Observations related to colors, sounds, or music Involves “five senses”: sight, sound, smell, taste, or hearing Observations related to age, weight, or height Observing interactions in public spaces, like bus rides or parks Hinges on the fact that the participants do not know they are being observed ![]() Utilizing coding and a strict observational schedule, researchers observe participants in order to count how often a particular phenomenon occursĬounting the number of times children laugh in a classroom Spending a few months in a hospital with patients suffering from a particular illness The researcher observes how the participants respond to their environment in “real-life” settings but does not influence their behavior in any wayĪlso occurs in “real-life” settings, but here, the researcher immerses themselves in the participant group over a period of time Here are some of the most common types to help you choose the best one for your observational study. There are many types of observation, and it can be challenging to tell the difference between them. Advantages and disadvantages of observational studies.However, the lack of control and treatment groups means that forming inferences is difficult, and there is a risk of confounding variables and observer bias impacting your analysis. This is often due to ethical or practical concerns that prevent the researcher from conducting a traditional experiment. Observational studies are generally used in hard science, medical, and social science fields. While quantitative observational studies exist, they are less common. These studies are often qualitative in nature and can be used for both exploratory and explanatory research purposes. There is no interference or manipulation of the research subjects, and no control and treatment groups. Try for free What Is an Observational Study? | Guide & ExamplesĪn observational study is used to answer a research question based purely on what the researcher observes. non-probability samplingĮliminate grammar errors and improve your writing with our free AI-powered grammar checker. ![]() ![]() ![]() The refractory period of a cardiac fiber is longer than the contraction itself, as a result tetanus cannot occur.After the plateau phase the fiber repolarizes by allowing K +ions to flow out of the cytosol and at the same time the Ca ++channels close.The combined build up of Ca ++ and K + ions causes a delay of up to 250 milliseconds (.25 sec).in addition the fast potassium ion (K +) channels close reducing their effux. ![]() At +30 mV, the Na + channels close decreasing potential, however the membrane then enters a plateau by allowing calcium ion (Ca ++ ) channels to open causing a them to also flow inside the cytosol.An action potential stimulates the contractile fibers to depolarize - voltage gated channels in the membrane to open allowing sodium ions to flow back in the cytosol.The resting membrane potential is created by actively pumping sodium ions (Na +) out of the fiber.The resting membrane potential of the cardiac muscle fiber is -90 mV inside the cell.Rapid, partial early repolarization, prolonged period of slow repolarization which is plateau phaseĪ wave of depolarization that begins in the pacemaker and spreads over the heart (it precedes contraction).Repolarization due to normal K+ effluxĪction Potential of Contractile Cardiac Cells Falling phase at about +20 mV the Ca-L channels close, voltage-gated K channels openĩ. At threshold sharp depolarization due to activation of Ca2+ L channels allow large influx of Ca++Ĩ. Slow influx of Ca++ further depolarizes bringing to threshold (-40mV)ħ. As depolarization proceeds Ca++ channels (Ca2+ T) open before threshold is reachedĦ. Gradual depolarization because K+ builds up and Na+ flows inwardĥ. Constant influx of Na+, no voltage-gated Na + channelsĤ. Decreased efflux of K+, membrane permeability decreases between APs, they slowly close at negative potentialsģ. Membrane slowly depolarizes “drifts” to thresholdĢ.The animation is followed by practice questions. Initiates an action potential which travels throughout heart down to the atrioventricular (AV) node, which slows down the AP before traveling to the atrioventricular bundle (bundle of His) and splits into the R/L bundle branches which spread into conduction myofibers (Purkinje fibers).Ĭlick here for an animation on the conduction system of the heart.They act as a pacemaker and a conduction system.Allow the atria to contract first then the ventricles contract.Use calcium influx (rather than sodium) for rising phase of the action potentialĪutorhythmic cells depolarize spontaneously but at different rates:.membrane slowly depolarizes “drifts” to threshold, initiates action potential, membrane repolarizes to -60 mV.Have “drifting” resting potentials called pacemaker potentials.Intercalated discs allow branching of the myocardium.have a different looking action potential fro other nerve cells due to calcium channels.normally do not produce action potentials.Superior/Inferior vena cava and coronary sinusĬlick here for an animation that summarizes the flow of blood through the heart. Circuit of vessels carrying blood between heart and other body systemsġ.Closed loop of vessels carrying blood between heart and lungs.Regulating blood supply - changes in contraction rate and force match blood delivery to changing metabolic needs.Routing blood, ensuring one-way blood flow, separates pulmonary and systemic circulations.Generating blood pressure to produce a gradient that pushes blood through the vascular system.Transport medium within which materials being transported are dissolved or suspended.Passageways through which blood is distributed from heart to all parts of body and back to heart.Serves as pump that establishes the pressure gradient needed for blood to flow to tissues.The parts of the circulatory system include: ![]() ![]() ![]() If it didn’t happen at the one of the Slams (and even the Aussie Open gets fuzzy by now), it’s as if it didn’t happen at all. I guess we can all succumb to the (bogus) “it’s only the majors that matter” mindset. I wrote the Racquet Reaction to this one on October 27 and called it "amazing." Last week, when I was trying to come up with my Top 10 match list, I didn’t even recall it until I did a more thorough search outside of the Slams. The first thing I should note is how quickly we forget about even the matches we love. 10, with a recent, and wild, three-set comeback win by Agnieszka Radwanska over Vera Zvonareva at the WTA's year-end championships in Istanbul. I’ll use these clips, as I have the last two years, to count down my own Top 10 matches of 2011 over the next two weeks. ![]() In these, you enter a sort of tennis utopia, a beautiful, taunting universe where every point ends with a winner and no one makes anything so gauche as an unforced error. This is where the trusty YouTube highlight reel comes in. It was a fine year of tennis, and it deserves a look back before we look ahead. It was too, as they say, soon.īut the Tennis Channel's concept is a sound one. Then Murray, after shanking a backhand, let out a primal howl in the direction of his box and I was happy to be able turn the channel. This looked better: The sun, the clouds, the polite applause, the clubhouse in the background-I missed London in summer. The next time I stopped by, I caught a few points of Jo-Wilfried Tsonga’s win over Andy Murray at Queens. I thought the network might be stretching the meaning of “best” a little thin. On my first visit, I saw a little of Victoria Azarenka’s 6-1, 6-4 blowout of Maria Sharapova in Key Biscayne. It has been a week: Do you miss tennis yet? For old times’ sake, I flipped over to the Tennis Channel twice this weekend to see how the network’s countdown of the Top 30 matches of 2011 was going. ![]() ![]() ![]() There might be a COVID-era pragmatism to the film’s sparse setup and ensemble, though at a more philosophical level, “A Perfect Day for Caribou” appears to unfold in a vacuum of community, a place and time when people have abandoned their obligations to others. Other characters - a hunter, a caretaker - mosey into the situation, glancing or sympathizing, before melting back into their own isolation. There’s little urgency in their quest, which takes on a dreamlike, fatalistic air, as if a small boy is merely emblematic of many things the two fathers are missing between them. As they comb desolate neighboring fields and forests, the pair share recollections and resentments from Nate’s upbringing, though the fluency of Herman’s earlier, unaccompanied monologue is nowhere to be found. The kid disappears in short order a reunion becomes a search party. For all their time apart, the two men have a certain shambling dejection in common, not to mention a hands-off parenting style: As they begin to haltingly talk through the years lost between them, ambling through the sleepy graveyard where Herman’s truck is parked, Nate instructs Ralph to run off and play. His plans to end his life thus unexpectedly postponed, he’s further surprised to find the twentysomething Nate with his own toddler Ralph (Oellis Levine) in tow. “I don’t want you just to know me as the father who killed himself,” he sighs an unexpected opportunity to mend that perception comes when Nate calls him out of the blue, and asks to meet. Addressing his adult son Nate, he nonetheless tellingly narrates his failed life story as if to a stranger, occasionally disrupting his own memories with stray stabs of random life advice: join a union, use vinegar to buff out spots on a car, don’t mess around with electrodes. ![]() ![]() “I don’t think there are any charms left for me in this life,” mutters weatherbeaten drifter Herman into a dictaphone, from the front seat of a pickup truck that has all his worldly possessions, such as they are, packed into it. It begins as Berrier’s show, the rumpled character actor holding our attention over the course of a lengthy, discursive introductory monologue that, we soon gather, is an audio suicide note of sorts. Still, it promises significant things from its young writer-director, who shows more formal nous and rigor than many neophyte directors of comparable U.S. Rutherford, however, is a less acidic, more gently perceptive writer of masculine dysfunction than Payne, and in its best moments, his debut reaches for the mournful everyday poetry of Wim Wenders’ “Paris, Texas” or Kelly Reichardt’s “Old Joy.” Elsewhere, the film feels a little determined in its minimalism, a little too cute in its brushes of absurdism. The gruffly dysfunctional father-son relationship at “Caribou’s” center, in conjunction with its spartan middle-American milieu and serene black-and-white lensing, will inevitably call Alexander Payne’s lauded “Nebraska” to mind for any viewers or marketers seeking comparison points. ![]() ![]() ![]() fast, pounding, or irregular heartbeat or pulse.Bigger, dilated, or enlarged pupils (black part of the eye).Get emergency help immediately if any of the following symptoms of overdose occur while taking aripiprazole: Symptoms of overdose large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs.itching, puffiness, or swelling of the eyelids or around the eyes, face, lips, or tongue.uncontrolled movements of the arms and legs.rapid or worm-like movements of the tongue.muscle spasm or jerking of all extremities.increased blinking or spasms of the eyelid.uncontrolled movements, especially of the face, neck, and back.muscle trembling, jerking, or stiffness.Although not all of these side effects may occur, if they do occur they may need medical attention.Ĭheck with your doctor immediately if any of the following side effects occur while taking aripiprazole: More common Serious side effects of AbilifyĪlong with its needed effects, aripiprazole (the active ingredient contained in Abilify) may cause some unwanted effects. Advise families and caregivers of the need for close observation and communication with the prescriber.The safety and efficacy of aripiprazole have not been established in pediatric patients. These studies did not show an increase in the risk of suicidal thoughts and behavior with antidepressant use in patients over age 24 there was a reduction in risk with antidepressant use in patients aged 65 and older.In patients of all ages who are started on antidepressant therapy, monitor closely for worsening, and for emergence of suicidal thoughts and behaviors. Antidepressants increased the risk of suicidal thoughts and behavior in children, adolescents, and young adults in short-term studies. Aripiprazole is not approved for the treatment of patients with dementia-related psychosis. Warning: Increased Mortality In Elderly Patients With Dementia-Related Psychosis And Suicidal Thoughts And Behaviors With Antidepressant DrugsElderly patients with dementia-related psychosis treated with antipsychotic drugs are at an increased risk of death. Oral route (Tablet Tablet, Disintegrating Solution) ![]() |